Lions vs. Giants odds Stafford, Detroit road underdogs on Monday Night Football Week 2 of the NFL season in a series that has historically favored the road team. Betting Line / Total: New York -3 / Points . a way it hasn't been in 16 years Been awhile since the Broncos got blasted like this. Updated: Sat, Sep 23 AM EDT. NOTES: Open Line: Consists of the first betting line received from one of our Las Vegas or Online sportsbooks. The Detroit Lions aren't just coming from behind to win games; NFL pick, via Odds Shark computer: Saints (NFL picks on every game) Also, that two-game losing streak consisted of a two-point loss to Denver.